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- Will algorithm mining revolutionize software development?
- Is there a core computational architecture in biological cells?
- Will generative content revolutionize the entertainment industry?
- How will computer experiments change the face of mathematics?
- Are there business structures founded on computation universality?
- What would an operating system for a swarm of microbots be like?
- What kinds of artificial physics can support quantum mechanics?
- Will artificial life arise spontaneously within the internet?
- Can one map the space of all possible economic systems?
- Will the next core computer architecture be discovered by search?
- Can we enumerate the morphologies of possible biological organisms?
- What pattern recognition algorithms can molecules implement?
- What does computational irreducibility mean for supercomputing?
- Is there an algorithm for telling if an object was designed?
- Will the most important nanomaterials be intrinsically random?
- Can a single rule design the complete structure of a building?
- Is there an absolute measure of elegance for programming languages?
- What is the network analog of a recursive function?
- Can we find the simplest undecidable problem in number theory?
- What would prove the Principle of Computational Equivalence?
- What will happen if kids learn cellular automata before algebra?
- What will be the first major industry created by mining the computational universe?

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